Taper up-off treatment of opium may reverse some dysregulations of gene expression patterns caused by four type of leukemia, AML, ALL, CML and CLL; a pilot animal model study

Leukemia is a group of lethal diseases characterized by hematological neoplasm with complex and abnormalities in proliferation bone marrow stem cells, that cause sever loss functional capacity hematopoietic tissue. Four most common types leukemia are included acute lymphoblastic (ALL), myeloid (AML), chronic lymphocytic (CLL) (CML). It has been reported opium besides pain killer effects, may have positive effects on cardiovascular disease treatments. Opium consider as potential treatment method cancer. The present study aimed to assess the gene expression pattern alterations rat models four (ALL, AML, CLL, CML) under taper up-off opium. Present was twelve group, referred type each studied three group. Group one contented normal rats, two model no 26 days period treatment. After scarification tissue were extracted. Then, RNA extraction cDNA synthesis had conducted tissues. Whole genome profiling using Affymetrix GeneChip Array Platform. Microarray results confirmed Real time PCR. analysis detected hundreds genes which involved Ontogenesis apoptosis, humoral immune system, tool like receptors, natural cells regulators metabolic pathways deregulated leukemic models, partially reregulated groups. Results showed reregulation affected patterns all leukemia. suggest could be re-regulator system novel for low side high viability.